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Immune cells can remove senescent cells. Mounting evidence indicates that immunotherapy targeting senescent cells combats ageing and chronic diseases and subsequently extends the healthy lifespan. 日前，发表于《Journal of Translational Internal Medicine》的综述“Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies”系统梳理了靶向衰老细胞的两大前沿方向——细胞外囊泡（EVs）疗法与免疫细胞疗法，这些策略正从实验室走向临床，为.
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免疫细胞可以清除衰老细胞，针对衰老细胞的免疫疗法可以对抗衰老和慢性疾病，从而延长健康寿命。 同时，Nature 杂志上的研究表示，NK细胞清除动物体内的衰老细胞，可使得寿命延长20%-30%。 相对比没有清除衰老细胞的动物，那些被清除了衰老细胞的小鼠年轻了6个月，相当于人类年轻数十年。 因此，免疫细胞疗法有望减缓衰老过程，预防和治疗与衰老相关的慢性疾病。 衰老细胞，这些本应退出历史舞台的细胞，却因种种原因在体内滞留，成为组织功能衰退和疾病发生的元凶。 它们不仅阻碍了正常细胞的更新与修复，还通过分泌有害物质扰乱周围环境，导致慢性炎症和组织损伤，最终引发一系列与年龄相关的疾病。 Here, we review how different components of the innate and adaptive immune systems, including natural killer cells, macrophages, neutrophils, dendritic cells, t cells and b cells, target.
